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Arch Neurol Chicago · Oct 1979
Case ReportsAmyotrophic lateral sclerosis with ophthalmoplegia. A clinicopathologic study.
- D G Harvey, R M Torack, and H E Rosenbaum.
- Arch Neurol Chicago. 1979 Oct 1;36(10):615-7.
AbstractOphthalmoplegia is rarely observed in patients with amyotrophic lateral sclerosis (ALS). We describe a patient with ALS in whom ophthalmoplegia, initially appearing midway in her course, progressed to total paralysis of extraocular movements by the time of death. In addition to the usual postmortem findings of ALS in the brain stem and spinal cord, there was extensive neuronal loss and gliosis involving the caudal portions of the dorsal and intermediate components of the oculomotor nuclei, the caudal part of the trochlear nuclei, and the abducens nuclei. This represents the first detailed report of the findings in the nuclei of cranial nerves III, IV, and VI in a patient with ALS and ophthalmoplegia.
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