• Xiao-Lan Lu, Xu-Jie Zhou, Jian-Ping Guo, Ru-Lin Jia, Yi Zhao, Quan Jiang, Xiang-Yuan Liu, Yi Liu, Ling-Yun Sun, Hong Zhang, and Zhan-Guo Li.
• Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.
• Chin. Med. J. 2011 Sep 1; 124 (18): 286328672863-7.

BackgroundA previous study has shown that rs548234 polymorphism at PRDM1-ATG5 region is associated with rheumatoid arthritis (RA) in Caucasian populations. The aim of this study was to investigate the effect of rs548234 polymorphism at PRDM1-ATG5 region on susceptibility to RA in Chinese Han population.MethodsWe genotyped 848 RA patients and 1431 matched healthy controls for rs548234 single-nucleotide polymorphism (SNP) with a predesigned TaqMan SNP genotyping assay. Association analyses were performed on the whole data set and on rheumatoid factors (RF) and anti-cyclic citrullinated peptides (anti-CCP) antibody. Finally, we carried out combined analysis of rs548234 association with RA based on the published data.ResultsNo significant difference in the genotype distribution between RA patients and healthy controls for rs548234 (C/T) polymorphism was found in Chinese Han population, neither in whole data set nor in stratified subsets, e.g. RF and anti-CCP status. Association analysis in different ethnic groups showed that rs548234 at PRDM1-ATG5 region was associated with RA in Caucasian ancestry but not in East Asian population.ConclusionsOur results showed no involvement of rs548234 at PRDM1-ATG5 region in the susceptibility or clinical relevance of RA in Chinese Han population.

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