• Jin Zhang, Detao Ding, Juxing Sun, Hui Zhang, YunBing Dai, Xiaoying Li, Xu Ma, Xiaoyu Li, and Yungang Wu.
• School of Clinical Medicine Jining Medical University, Jining, Shandong, China.
• Medicine (Baltimore). 2022 Dec 2; 101 (48): e32203e32203.

RationaleMultiple extramedullary plasmacytoma (EMP) of the head and neck is rare and a definitive first-line treatment has not been established. EMP successively as a benign mass occurring in multiple areas of the head and neck is rare. This report describes an atypical case with EMP occurring in multiple areas of the head and neck.Patient ConcernsA 35-year-old woman was admitted due to complaints of sore throat discomfort accompanied by hoarseness. The patient had undergone surgical excision of the thyroid gland and parotid gland excision several years ago. Postoperative pathological examination both indicated EMP. This time, the woman suffered EMP in head and neck who was treated with a simple surgery.DiagnosisPostoperative pathological examination of the tumor indicated EMP, and histopathological findings revealed the tumor to be a plasmacytoma. Immunopathological examination were consistent with the diagnosis of EMP.InterventionsThe patient underwent surgical resection without radiotherapy.OutcomesHistopathological and immunopathological examination findings revealed the tumor to be EMP. The patient was recurrence-free and did not progress to multiple myeloma (MM) during 19 months follow-up.LessonsIncreasing the awareness of EMP of head and neck is warranted. Our case confirmed that surgical excision is beneficial in the treatment of small, localized EMP.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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