• Medicine · Sep 2017

    Case Reports

    Percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue for advanced pancreatic carcinoma: Case Report.

    • Biao Yang, Jian-Ping He, Min-Lan Yuan, Wei Li, He Jiao, Xin You, Xing-Rong Liu, Jian Zhao, Chun-Lin Li, Xiao-Bo Fu, Zheng-Yin Liao, and Cheng Yi.
    • Department of Abdominal Oncology, Cancer Center and State Key Laboratory of Biotherapy Department of Psychiatry Department of Radiology, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.
    • Medicine (Baltimore). 2017 Sep 1; 96 (37): e8018e8018.

    RationaleThe aim of this study was to determine the effectiveness of intratumoral injection of chemotherapeutics in improving the quality of life and survival of patients with pancreatic carcinoma.Patient ConcernsWe present a case series of 5 patients with unresectable pancreatic adenocarcinoma.DiagnosesPatients diagnosed with unresectable poorly differentiated pancreatic ductal adenocarcinoma by intraoperative frozen biopsyor percutaneous biopsy.InterventionsFive patients with unresectable pancreatic adenocarcinoma received a computed tomography-guided percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue.OutcomesMean overall survival was 16.2 ± 3.7 months. Local control rates were 100% and 80% at postoperative 3 and 6 months, respectively. Mean Visual Analogue Scale pain score decreased from 7.2 ± .84 preoperatively to 2 ± 1.22 at postoperative 4 weeks. There were no complications associated with the procedure.LessonsPercutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue for advanced pancreatic may be safe and effective.

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