• Carmela Protano, Federica Valeriani, Andrea De Giorgi, Daniela Marotta, Francesca Ubaldi, Christian Napoli, Giorgio Liguori, Vincenzo Romano Spica, Matteo Vitali, and Francesca Gallè.
• Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. Electronic address: carmela.protano@uniroma1.it.
• Nutrition. 2023 Mar 1; 107: 111904111904.

ObjectivesEnergy drink (ED) use is promoted to stimulate mental and/or physical activity, and their popularity has increased over the years, especially among young people. However, the use of EDs is often improper, and can induce adverse effects for human health. The purpose of this systematic review and meta-analysis was to analyze the literature to characterize the prevalence of ED consumption and motivations for use among undergraduate students. Furthermore, adverse effects and health-related behaviors associated with ED consumption were explored.MethodsThis systematic review was carried out according to the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines, and the PubMed, Scopus, and Web of Science databases were used for data research.ResultsA total of 71 articles published between 2007 and 2021 met the inclusion criteria and were included in the review. The estimated overall prevalence of ED consumption was 42.9% in undergraduate students (95% confidence interval, 42.5%-43.3%), with significant heterogeneity among studies (Q test: P < 0.001; I2 = 99.4%). The main reasons for use were engagement in study, projects or examinations, stay awake or alert, and physical activity/sport engagement. Sleep disturbance and increased heart rate or blood pressure were the most commonly reported adverse effects. ED consumption was frequently associated with alcohol use and smoking.ConclusionsThese findings suggest that the inappropriate use of EDs and related unhealthy behaviors should be identified early, and addressed through effective educational interventions..Copyright © 2022 Elsevier Inc. All rights reserved.

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