• Xiao-Yi Wang, Su-Hang Xie, Yu-Jia Zhang, Si-Yi Zhu, Rui-Shi Zhang, Lin Wang, Yuan Feng, Wei-Ran Wu, Dan Xiang, Yuan Liao, and Cheng-Qi He.
• School of Rehabilitation Sciences, West China School of Medicine, Sichuan University, Chengdu, P.R. China.
• Medicine (Baltimore). 2022 Dec 16; 101 (50): e31841e31841.

BackgroundKnee osteoarthritis (KOA) is a chronic musculoskeletal disease affecting the entire joint. Exercise therapy is the core treatment plan for non-surgical treatment of KOA, and tele-rehabilitation is also applied to KOA, but there is a lack of research on the comparison of pain and function recovery between different exercise methods combined Internet respectively. The study aims to compare the effects of power cycling and quadriceps training combined with online guidance separately on KOA mitigation of pain, recovery of function, quality of life, and adherence of participants in the community, compared to the control group.MethodsThis study is a single-blind, 12-week parallel randomized controlled trial. Seventy-two participants aged ≥ 50 years with KOA will be randomized into either the power cycling group, the quadriceps group or the control group. The intervention will be performed three times per week during 12 weeks. Outcome measures will be assessed at baseline, and at 4, 8, and 12 weeks after allocation. The primary outcome will be self-reported pain, assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale. Secondary outcomes will include mitigation of knee pain, quality of life, improvement of functional physical performance, adherence of participants.DiscussionBy summarizing the study's strengths and limitations, this trial results may guide tele-rehabilitation of KOA in the community.Trial registration: The study was registered in the clinical trial registry ChiCTR2200059255, 27/04/2022.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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