• Anticancer research · Jul 2014

    Case Reports

    First report of trastuzumab treatment after postoperative Takotsubo cardiomyopathy.

    • Mickael Burgy, Hélène Brossat, Philippe Barthelemy, Alessio Imperiale, Annie Trinh, Chafia Assia Hazam, Jean-Pierre Bergerat, and Carole Mathelin.
    • Department of Medical Oncology, Civil Hospital, Strasbourg, France.
    • Anticancer Res. 2014 Jul 1;34(7):3579-82.

    BackgroundTrastuzumab is a humanized monoclonal antibody used for the treatment of HER2-positive breast cancer. Cardiotoxicity is a well-known adverse event of trastuzumab use but little has been documented regarding its use in patients with a history of cardiac disease.Case ReportWe describe a case in which trastuzumab treatment was administered to a 40-year-old female patient with early breast cancer after acute heart failure secondary to postoperative Takotsubo cardiomyopathy. After one year of follow-up with close monitoring by echocardiography, there have been no heart-related symptoms. Additional surgery was performed because of positive resection margins at first surgery, without complications, despite the risk of recurrence of Takotsubo cardiomyopathy.ConclusionTrastuzumab can be safely administered after acute heart failure secondary to postoperative Takotsubo cardiomyopathy.Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…