• Michael J Pajor, Brit Long, Alex Koyfman, and Stephen Y Liang.
• Department of Emergency Medicine, Washington University School of Medicine, St Louis, MO, USA. Electronic address: m.j.pajor@wustl.edu.
• Am J Emerg Med. 2023 Mar 1; 65: 768376-83.

IntroductionAcute bacterial meningitis in adults is a rare but serious condition that carries a high rate of morbidity.ObjectiveThis review highlights pearls and pitfalls of acute bacterial meningitis in adults, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence.DiscussionMeningitis encompasses a broad spectrum of disease involving inflammation of the meninges and subarachnoid space. It classically presents with fever, nuchal rigidity, and altered mental status, but this triad is not present in all cases. Up to 95% of patients will have at least two of the following four cardinal symptoms: fever, nuchal rigidity, altered mental status, and headache. The most common bacterial etiologies are S. pneumoniae and N. meningitidis. Cerebrospinal fluid testing obtained by lumbar puncture remains the gold standard in diagnosis. Head computed tomography prior to lumbar puncture may not be necessary in most patients. Empiric treatment consists of vancomycin, ceftriaxone, and dexamethasone. Elevated intracranial pressure should be managed using established neurocritical care strategies.ConclusionA better understanding of the pearls and pitfalls of acute bacterial meningitis can assist emergency clinicians in pursuing its timely diagnosis and management.Published by Elsevier Inc.

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