• Liren Yang, Guilan Xie, Wenfang Yang, Ruiqi Wang, Boxing Zhang, Mengmeng Xu, Landi Sun, Xu Xu, Wanwan Xiang, Xiaoyi Cui, Yiwen Luo, and Mei Chun Chung.
• Department of Obstetrics and Gynecology, Maternal & Child Health Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China.
• Ann. Med. 2023 Dec 1; 55 (1): 325334325-334.

IntroductionLong-term exposure to air pollution is known to be harmful to preterm birth (PTB), but little is known about the short-term effects. This study aims to quantify the short-term effect of particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5), ≤10 μm (PM10) and nitrogen dioxide (NO2) on PTB.Materials And MethodsA total of 18,826 singleton PTBs were collected during the study period. Poisson regression model combined with the distributed lag non-linear model was applied to evaluate the short-term effects of PTBs and air pollutants.ResultsMaternal exposure to NO2 was significantly associated increased risk of PTB at Lag1 (RR: 1.025, 95%CI: 1.003-1.047). In the moving average model, maternal exposure to NO2 significantly increased the risk of PTB at Lag01 (RR: 1.029, 95%CI: 1.004-1.054). In the cumulative model, maternal exposure to NO2 significant increased the risk of PTB at Cum01 (RR:1.026, 95%CI: 1.002-1.051), Cum02 (RR: 1.030, 95%CI: 1.003-1.059), and Cum03 (RR: 1.033, 95%CI: 1.002-1.066). The effects of PM2.5, PM10 and NO2 on PTB were significant and greater in the cold season than the warm season.ConclusionsMaternal exposure to NO2, PM2.5 and PM10 before delivery has a significant risk for PTB, particularly in the cold season.Key messagesMaternal exposure to NO2 was significant associated with an increased risk of preterm birth at the day 1 before delivery.Particle matter (PM2.5 and PM10) showed a significant short-term effect on preterm birth in the cold season.The effects of air pollutants on preterm birth was greater in the cold season compared with the warm season.

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