• Bastian Dislich, Dennis Hoch, Stefan Dirnhofer, Urban Novak, and Yara Banz.
• Institute of Pathology, University of Bern, Bern, Switzerland.
• Medicine (Baltimore). 2022 Dec 23; 101 (51): e32457e32457.

RationaleThe diagnosis of lymphoma in routine diagnostics can be challenging due to clinical, morphological and immunphenotypical overlap with unusual reactive processes termed "pseudolymphomas."Patient Concerns45-year-old male that underwent surgical debridement for a necrotizing fasciitis of the thigh with concomitant excision of a regional lymph node.DiagnosesThe lymph node demonstrated an architecture-effacing activation and proliferation of lymphoblasts and was initially misdiagnosed as an aggressive lymphoma. Only in consideration of the clinical context and with the help of additional immunohistochemical and molecular analyses the final diagnosis of a reactive lymphadenopathy could be made.InterventionsNo further therapy was required after the final diagnosis of a reactive lymphadenopathy was made.OutcomesThe clinical follow-up was unremarkable, with no evidence of residual disease after 6 months.LessonsThis case report adds the parafollicular activation and proliferation of blasts and plasmablasts in the drainage area of an active infection to the spectrum of "pseudolymphomas" and reiterizes the importance of placing histopathological findings in the proper context.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

15 keywords...

hide…