• Kabelo Mokgalaboni, Phiwayinkosi V Dludla, and Bongani B Nkambule.
• Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, FL, South Africa.
• Medicine (Baltimore). 2022 Dec 23; 101 (51): e32313e32313.

BackgroundDue to contradicting findings on impact of statins on endothelial function in type 2 diabetes mellitus especially across the randomized controlled trials (RCTs). With this systematic review, we aim to evaluate whether the use of statins improves endothelial function in adults with type 2 diabetes. We will further highlight if these biomarkers are ideal therapeutic targets for risk for atherosclerosis and cardiovascular disease.MethodsThis protocol was carried out according to the preferred reporting items for systematic review and meta-analysis protocols-2015 guideline. The online databases, such as MEDLINE, Scopus, and Web of Sciences, will be targeted using the medical subject heading terms (MeSH) and text words. The review will include clinical studies on the effect of statins on markers of endothelial function in type 2 diabetes. The Cochrane risk of bias guideline will be used to assess the quality and risk of bias. We are planning to use the grading of recommendation assessment, development, and evaluation approach to evaluate the strength and quality of evidence.ResultsThis study will not involve human samples and patient data; hence ethics approval will not be required. The findings will be presented in journal clubs and conferences and published in peer-reviewed journals.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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