• Po-Hung Tseng, Shu-Han Chuang, Yueh Pan, Hung-Jen Shih, Chin-Pao Chang, and Sheng-Hsien Huang.
• Division of Urology, Department of Surgery, Changhua Christian Hospital, Changhua, TaiwanROC.
• Medicine (Baltimore). 2022 Dec 30; 101 (52): e32524e32524.

BackgroundSince the mass vaccination for COVID-19, several case reports indicated the risk of autoimmune disease flare-ups after the vaccination. Among them, COVID-19 vaccine-induced glomerular diseases have drawn attention worldwide. The cases demonstrating the association between the mRNA vaccine and IgA nephropathy (IgAN) exacerbation had been noticed. Mostly mentioned, the flare-ups usually occurred after the second dose.MethodsWe present a Taiwanese female with IgAN who developed gross hematuria within only six hours after the first dose of the Moderna vaccine.ResultsSix hours after the first dose of Moderna vaccine on 8 June 2021, the patient developed gross hematuria and significantly decreased urine output. All symptoms resolved spontaneously on the fifth day after the vaccination without any intervention. On the fourth day after the vaccination, the patient were able to back to her original condition.ConclusionThis was an intriguing case of IgAN flare-up following the first dose of mRNA-based COVID-19 vaccination.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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