• Simone Paulo Mateus, Marcelo Ribeiro-Alves, Raquel Esteves Brandão Salles, Walter Costa, Claudia Henrique da Costa, Agnaldo José Lopes, Thiago Prudente Bártholo, Thiago Thomaz Mafort, Bernardo Rangel Tura, and Rogério Rufino.
• Department of Chest Diseases, Rio de Janeiro State University, Pulmonology Service, Rio de Janeiro, Brazil.
• Medicine (Baltimore). 2022 Dec 30; 101 (52): e32537e32537.

AbstractTo identify the risk factors associated with all-cause mortality in patients with noncystic fibrosis bronchiectasis (NCFB). This prospective cohort study included 120 adult patients with NCFB, who were regularly treated at a specialized outpatient clinic of a university hospital between January 2017 and June 2020. All patients were diagnosed using high-resolution computed tomography. Demographic and clinical data, pulmonary function tests, and the Euro-quality-of-life 5-domain 3-level questionnaire were analyzed. The factors associated with death were determined using the Cox proportional hazards model. The all-cause mortality rate at 41 months was 10.8%. Adjusted multivariate analysis showed that the main contributing predictors for mortality were female sex, smoking, diabetes, chronic obstructive pulmonary disease, emergency visits, use of antibiotics due to exacerbation, secretion color change, exacerbation, predicted forced expiratory volume in 1 second, predicted forced vital capacity, lack of respiratory physiotherapy, absence of vaccination against pneumococci, and mobility domain. Multiple factors contribute to unfavorable outcomes in patients with NCFB, and early recognition of these factors may improve care management.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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