• Medicine · Dec 2022

    Meta Analysis

    Effectiveness of combined pregabalin and celecoxib for treatment of acute postoperative pain: A meta-analysis and systematic review.

    • Jing-Mei Ni, Xuan Zhu, and Ping Wang.
    • Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
    • Medicine (Baltimore). 2022 Dec 30; 101 (52): e32080e32080.

    ObjectiveTo estimate the acute analgesic efficacy of combined Pregabalin and Celecoxib after operation via a systematic review and meta-analysis.MethodsStudies for inclusion were randomized controlled trials, reporting on relevant outcomes (0-6 hours, 24 hours, 7 days pain scores) with treatment with combined Pregabalin and Celecoxib.ResultsThe pooled results from meta-analysis demonstrated that compared with placebo, combined Pregabalin and Celecoxib reduced pain scores at 0 to 6 hours in 3 articles, 24 hours in 5 articles, 7 days in 2 articles (standard mean difference [SMD], -3.10 at 0-6 hours, -2.80 at 24 hours, -1.32 at 7 days, respectively). Combined Pregabalin and Celecoxib could significantly reduce the postoperative narcotic consumption in 3 studies (SMD, -1.99 at 36 hour).DiscussionThis work suggested that combined Pregabalin and Celecoxib were efficacious in reduction of postoperative pain and narcotic requirements after surgery, whereas more trials are needed to further identify the efficacy of combined Pregabalin and Celecoxib in the management of acute postoperative pain.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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