• Miloš Pantelić, Ljiljana Gvozdenovic, Milana Panjković, Marko Stojić, Dragan Stajić, Aleksandra Petrić, Sonja Pop Trajković, Milan Trenkić, Dušan Simić, Lazar Živadinović, and Aleksandar Živadinović.
• Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
• Medicine (Baltimore). 2022 Dec 30; 101 (52): e32552e32552.

IntroductionUndifferentiated uterine sarcoma is a rare histological subtype of uterine sarcoma. This study aimed to summarize the clinical and pathological presentation of this case.Case ReportA 51-years-old patient was admitted to the clinic because of severe pain in the lower abdomen, and scanty bleeding from the genitals. Gynecological examination revealed an enlarged uterus. Conventional and Doppler transvaginal sonography detected a tumorously altered uterus with a maximum diameter of 20 cm a tumefaction with unclear borders and a diameter of 10 cm, with hyperechoic and hypoechoic fields within the tumefaction, presenting pathological vascularization and reduced values of the (Pulsatile index  ≤ 1) and (Resistance index  ≤ 0.40). Preoperatively, the chest, abdomen, and pelvis were examined. The patient underwent surgery and total abdominal hysterectomy with bilateral salpingo-oophorectomy, and partial omentectomy, with complete removal of the tumor. A pathohistological diagnosis, of undifferentiated uterine sarcoma, was made by excluding other types of uterine sarcomas. At the control examination after completion of chemotherapy, recurrence was ascertained.Conclusionundifferentiated uterine sarcoma is an aggressive malignant tumor that in most cases shows rapid progression of the disease after complete resection of the tumor, with a poor prognosis.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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