• Sifeng Qu, Weiwei Li, Yuan Yao, and Huangwei Huang.
• Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, China.
• Medicine (Baltimore). 2022 Dec 30; 101 (52): e32529e32529.

RationaleEmbryonal rhabdomyosarcoma (ERMS) is a major subtype of rhabdomyosarcoma, mainly affect children. There is seldom report for perineal ERMS in adults, since its rare location and the age.Patient ConcernsA 20-year old male adult was admitted due to the perineal mass.DiagnosesDiagnosis by histopathological examination of the biopsy sample was ERMS. Magnetic resonance imaging showed the tumor was found in the perineal region, with metastasis to pelvic cavity, right testis, lymph nodes and bone.InterventionsThe patient received Isophosphamide and Epirubicin for 4 cycles, followed by Irinotecan and Vindesine Sulfate for 2 cycles, then cisplatin, Dacarbazine and Apatinib for 3 cycles.OutcomeThe patient showed no response to chemotherapy.LessonsPerineal ERMS in adults is very rare. There is still no standard therapy for adult ERMS. Personalized therapy might be promising treatment for each individual.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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