• Caterina Formica, Simona De Salvo, Francesco Corallo, Desiree Latella, Katia Mìcchia, Lilla Bonanno, Angelo Quartarone, and Silvia Marino.
• IRCCS Centro Neurolesi "Bonino Pulejo", Messina, Italy.
• Medicine (Baltimore). 2022 Dec 30; 101 (52): e32526e32526.

ObjectiveThe aim of this study is to verify the functional activation in a patient with anosognosia for hemiplegia following left brain lesions.MethodsWe report a case of a 53-year-old right-handed female patient. She came to our rehabilitative unit with a diagnosis of an ischemic major stroke in the left internal carotid artery and important hemiplegia to the right side. She underwent functional magnetic resonance imaging (fMRI), during which she performed a motor imagery task.ResultsThe fMRI assessment showed an ischemic lesion in the frontotemporal and insular left areas. In the fMRI experiment, we revealed activation of the residual neural patterns of both hemispheres.ConclusionWe underlined an interest in the compensation mechanism that involved neural networks near brain lesions and some areas of the contro-lesional hemisphere, suggesting that the synaptic plasticity permitted an intra and inter-hemispheric reorganization of the cerebral system.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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