• Su Hyeon Choi, Eun-Young Nam, and Ji Hye Hwang.
• College of Korean Medicine, Gachon University, Seongnam, Republic of Korea.
• Medicine (Baltimore). 2022 Dec 9; 101 (49): e32267e32267.

BackgroundFractures are a condition in which bone continuity is lost or linear deformity occurs. They are a worldwide public health problem and a significant economic burden. The purpose of this study is to analyze the efficacy of Chinese patent medicine containing pyrite (CPMP) through systematic review and meta-analysis of fracture clinical data.MethodsA literature search will be carried out from the inception of CPMP studies to September 2022 using EMBASE, PubMed, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Korean Studies Information Service System, National Digital Science Library, and Oriental Medicine Advanced Searching Integrated System. Randomized controlled trials which include CPMP will be considered as eligible regardless of the type of fracture. After screening the literature, extracting the data, and assessing the risk of bias from the included studies, a meta-analysis will be performed using Review Manager version 5.4.ResultsThis study is expected to provide evidence for the efficacy and safety of CPMP for fractures.ConclusionOur findings will provide evidence to determine whether CPMP can be an effective intervention for patients with fractures, which would expand the possible treatment options.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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