• Zhaowei Sun, Xiaozhi Sun, Jingyun Guo, Xueliang Li, Qinlei Wang, Na Su, Menshou Chen, Guanghua Cao, Yanan Yu, Maobing Wang, Haoran Li, Haochen Zhong, Hao Zou, Kai Ma, Fangzhen Shen, Bingyuan Zhang, and Yujie Feng.
• Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
• Medicine (Baltimore). 2022 Dec 9; 101 (49): e32250e32250.

AbstractThe study was designed to discuss the effect of stratification factors in the Mayo staging on the prognosis of hilar cholangiocarcinoma (HCCA) patients, and to evaluate the predictive value of the Mayo staging on the prognosis. The Kaplan-Meier survival curve and Log-rank test were used to perform univariate analysis on each index and obtain statistically significant influencing factors. The Kaplan-Meier survival curve and Log-rank test were used to analyze the correlation between the two staging systems and the survival period. The receiver operating characteristic (ROC) curves were used for each single staging system trend analysis, and comparison of their curve area to determine prognosis prediction ability for patients with HCCA. According to Kaplan-Meier survival curve changes and Log-rank test results, it was found that both staging systems were correlated with the survival time of the patients (P < .001). Through a pairwise comparison within the stages, it was found that the heterogeneity between the stages within the Mayo staging is very good, which was better than the TNM staging. A single trend analysis of the prognostic assessment capabilities of the two systems found that the area under the ROC curve of Mayo staging system (AUC = 0.587) was the largest and better than the TNM staging system (AUC = 0.501). Mayo staging can be used for preoperative patient prognosis assessment which can provide better stratification ability based on a single-center small sample study, and the predictive value is better than TNM staging.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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