• Transl Res · Aug 2018

    Review

    The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis.

    • Silke Meiners, John Evankovich, and Rama K Mallampalli.
    • Comprehensive Pneumology Center (CPC), University Hospital, Ludwig Maximilians University, Helmholtz Zentrum München, Germany; Comprehensive Pneumology Center, Munich (CPC-M), Germany; Member of the German Center for Lung Research (DZL), Munich, Germany. Electronic address: silke.meiners@helmholtz-muenchen.de.
    • Transl Res. 2018 Aug 1; 198: 172817-28.

    AbstractThe present review aims to summarize available knowledge on the role of the ubiquitin-proteasome system (UPS) in the pathogenesis of scleroderma and scleroderma-related disease mechanisms. This will provide the reader with a more mechanistic understanding of disease pathogenesis and help to identify putative novel targets within the UPS for potential therapeutic intervention. Because of the heterogenous manifestations of scleroderma, we will primarily focus on conserved mechanisms that are involved in the development of lung scleroderma phenotypes.Copyright © 2018 Elsevier Inc. All rights reserved.

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