• Clin Oncol (R Coll Radiol) · Jan 1995

    Does dexamethasone leucocytosis facilitate full dosage adjuvant chemotherapy for breast cancer?

    • G J Rees.
    • Royal United Hospital, Bath, UK.
    • Clin Oncol (R Coll Radiol). 1995 Jan 1;7(4):257-8.

    AbstractThis is a retrospective analysis of breast cancer patients given adjuvant 'CMF' cytotoxic chemotherapy. It examines the impact on full blood counts of introducing dexamethasone as a prophylactic antiemetic the day before injections. Dexamethasone reduced leucopenia on injection due days. Twelve of 13 patients treated before the introduction of prophylactic dexamethasone, but only eight of 21 patients treated after, experience dose reduction or delay due to leucopenia (P < 0.01). Dexamethasone facilitated the administration of chemotherapy according to schedule.

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