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JNMA J Nepal Med Assoc · Dec 2022
Case ReportsIntracranial Calcification and Seizure with Down Syndrome: A Case Report.
- Nilshan Rai, Monika Thapa, Merina Pokharel, Jinee Acharya, and Dhirendra Yadav.
- KIST Medical College and Teaching Hospital, Gwarko, Lalitpur, Nepal.
- JNMA J Nepal Med Assoc. 2022 Dec 1; 60 (256): 106310651063-1065.
UnlabelledDown syndrome is a genetic disorder caused by an extra copy of chromosome number 21. New onset of seizure in adults with Down syndrome is rare. The exact pathogenesis of intracranial calcification and seizure in Down syndrome is unknown, however, a possible association between hypocalcemia and vitamin D deficiency in Down syndrome was reported. An 18-year-old girl with nasal bridge, mongoloid slants, clinodactyly and saddle gap of toes, and prominent Downs phenotypes was present with a low level of parathyroid hormone, calcium, and vitamin D. Due to a higher prevalence of intracranial calcification in people with Down syndrome, there is an increased possibility of hypocalcemia and vitamin D deficiency. Hence, serum levels of calcium and vitamin D should always be checked before starting treatment with anti-epileptic drugs.Keywordsbasal ganglia; Down syndrome; seizure; trisomy 21.
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