• Yasemin Akcaalan, Ersin Gurkan Dumlu, Ebru Menekse, Mustafa Cem Yilmaz, Ezgi Erkilic, Betul Ogut, and Aylin Sepıcı Dıncel.
• From the Department of Anesthesia and Reanimation (Akcaalan, Yilmaz, Erkilic), Ankara City Hospital, from the Department of General Surgery (Dumlu, Menekse), Ankara Yıldırım Beyazıt University, from the Department of Pathology (Ogut); and from the Department of Biochemistry (Dıncel), Medicine Faculty, Ankara Gazi University, Ankara, Turkey.
• Saudi Med J. 2023 Feb 1; 44 (2): 171177171-177.

ObjectivesTo experimentally evaluate the effects of preoperative fasting duration on distant organ liver in renal ischaemia-reperfusion (IR) injury.MethodsThis is an experimental study. In the study, 3 groups were formed. In Group A, abdominal laparotomy was carried out after 12 hours of preoperative fasting without any IR damage. In Group B, IR injury was carried out after 12 hours of preoperative fasting, and abdominal laparotomy was carried out, in Group C after 2 hours of fasting after IR injury. Apoptosis, congestion, balloon degeneration, nuclear pleomorphism, and leukocyte infiltration were examined histopathologically and tumor necrosis factor-alpha (TNF-α), interleukin (IL) -1 beta, IL-6, and IL-10 were evaluated biochemically.ResultsA statistically significant difference was determined between the groups in respect of postoperative IL-10 levels (p=0.020) with significantly lower levels determined in Group C than in Groups A and B (p=0.021). Similar rates of mild nuclear polymorphism were seen with no statistically significant difference determined between the groups (p>0.167). A statistically significant difference was determined between the groups in respect of the congestion scores (p<0.001), with a lower score in Group C than in Groups A and B, where the scores were similar (p<0.001, p=0.017).ConclusionWith this result, it would be correct to say that the short preoperative fasting period has protective effects on the liver tissue.Copyright: © Saudi Medical Journal.

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