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Case Reports
An opportunistic infection associated with ruxolitinib, a novel janus kinase 1,2 inhibitor.
- Nicholas G Wysham, Donald R Sullivan, and Gopal Allada.
- Department of Internal Medicine, Oregon Health and Science University, Portland, OR.
- Chest. 2013 May 1; 143 (5): 1478-1479.
AbstractWe report a case of Cryptococcus neoformans pneumonia in a patient taking ruxolitinib, a janus kinase 1,2 inhibitor approved for the treatment of myelofibrosis. We hypothesize that ruxolitinib contributed to this infection through its effects on cell-mediated immunity. Clinicians should be aware of the potential for intracellular or opportunistic infections associated with this novel drug class.
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