• Chest · May 2013

    Case Reports

    An opportunistic infection associated with ruxolitinib, a novel janus kinase 1,2 inhibitor.

    • Nicholas G Wysham, Donald R Sullivan, and Gopal Allada.
    • Department of Internal Medicine, Oregon Health and Science University, Portland, OR.
    • Chest. 2013 May 1; 143 (5): 1478-1479.

    AbstractWe report a case of Cryptococcus neoformans pneumonia in a patient taking ruxolitinib, a janus kinase 1,2 inhibitor approved for the treatment of myelofibrosis. We hypothesize that ruxolitinib contributed to this infection through its effects on cell-mediated immunity. Clinicians should be aware of the potential for intracellular or opportunistic infections associated with this novel drug class.

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