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Acta clinica Croatica · Aug 2022
PENTRAXIN 3 LEVELS CORRELATE WELL WITH DISEASE SEVERITY AT ADMISSION IN COVID-19 PATIENTS.
- Mehmet Emirhan Işık, Ramazan Korkusuz, Gülçin Erdal Şahingöz, Arzu Cennet Işık, Ali Karagöz, Nilgün Işıksaçan, Sevgi Kalkanlı Taş, and Kadriye Kart Yaşar.
- University of Health Sciences, Koşuyolu High Specialization Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey.
- Acta Clin Croat. 2022 Aug 1; 61 (2): 303310303-310.
AbstractPentraxin 3 (PTX3), a long pentraxin, is not only released from dendritic cells and neutrophils but also from epithelial and endothelial cells such as alveolar epithelium. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initially activates the innate immune system, causing a complex immune response. Clinical and experimental studies suggest that PTX3, a locally and systemically secreted marker, can be used as a predictor of the severity and mortality in respiratory infections. In the current study, serum PTX3 levels in patients hospitalized with COVID-19 were found to be significantly increased at admission and showed significant association with the disease severity.
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