• Tohoku J. Exp. Med. · May 2023

    Case Reports

    A Case of Miller Fisher Syndrome with Cerebellar Hypoperfusion.

    • Kaori Sumi, Noriyuki Kimura, Yuko Watanabe, Kenichi Yabuuchi, and Etsuro Matsubara.
    • Department of Neurology, Graduate School of Medicine, Oita University.
    • Tohoku J. Exp. Med. 2023 May 17; 260 (1): 475047-50.

    AbstractWe report a case of a 76-year-old man with Miller Fisher syndrome presenting with acute ophthalmoplegia and ataxia. Cerebrospinal fluid analysis showed normocytosis with an increased protein level. Serum anti-GQ1b IgG and anti-GT1a IgG antibodies were positive. Based on these results, the patient was diagnosed with Miller Fisher syndrome. He was treated with two courses of intravenous immunoglobulin, which improved his neurological symptoms. Brain perfusion single-photon emission computed tomography showed that cerebellar blood flow was decreased in the acute stage of the disease and improved after treatment. Although the prevailing view is that ataxia in Miller Fisher syndrome patients is of a peripheral origin, this case suggests that cerebellar hypoperfusion contributes to the development of ataxia in Miller Fisher syndrome.

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