Cytokine Release Syndrome in the Pediatric Population and

Critical care clinics · Apr 2023

Review

Cytokine Release Syndrome in the Pediatric Population and Implications for Intensive Care Management.

Cytokine release syndrome represents a spectrum of disease varying from fever alone to multiorgan system failure. Most commonly seen following treatment with chimeric antigen receptor T cell therapy, it is increasingly being described with other immunotherapies as well as following hematopoietic stem cell transplant. ⋯ Given the high risk of cardiopulmonary involvement, critical care providers must be familiar with the cause, symptoms, and therapeutic options. Current treatment modalities focus on immunosuppression and targeted cytokine therapy.

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- Juliana Romano, Eric Wilsterman, Megan Toal, and Christine Joyce.
- Department of Pediatrics, Division of Pediatric Critical Care Medicine, Weill Cornell Medicine, 525 East 68th Street, M508, New York, NY 10065, USA. Electronic address: jur9084@nyp.org.
- Crit Care Clin. 2023 Apr 1; 39 (2): 277285277-285.
AbstractCytokine release syndrome represents a spectrum of disease varying from fever alone to multiorgan system failure. Most commonly seen following treatment with chimeric antigen receptor T cell therapy, it is increasingly being described with other immunotherapies as well as following hematopoietic stem cell transplant. As its symptoms are nonspecific, awareness is key to timely diagnosis and initiation of treatment. Given the high risk of cardiopulmonary involvement, critical care providers must be familiar with the cause, symptoms, and therapeutic options. Current treatment modalities focus on immunosuppression and targeted cytokine therapy.Copyright © 2022 Elsevier Inc. All rights reserved.

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Cytokine Release Syndrome in the Pediatric Population and Implications for Intensive Care Management.

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