• Xiwu Chen, Jinhui Hu, Kaiwei Li, Sheng Liu, Qin Ye, and Baocen Cao.
• Department of Pediatrics, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei 435000, China.
• Afr Health Sci. 2022 Sep 1; 22 (3): 307316307-316.

BackgroundThe relationship between Q576R polymorphism of IL-4 receptor (IL-4R) gene and pediatric asthma risk is still undefined. To this end, this meta-analysis was performed to explore the above controversy.MethodsIn this study, we systemically retrieved CNKI, EMBASE, Web of Science, Scopus, Science direct and Pub Med to collect relevant researches, followed by calculation of odds ratio (OR) along with 95% confidence intervals (CIs). STATA 12.0 software was employed in this meta-analysis.ResultsWe found an association between IL-4R Q576R polymorphism and pediatric asthma risk (GG vs AA: OR = 3.75, 95% CI = 1.89-7.45; AG vs AA: OR = 2.15, 95% CI = 1.36-3.39; the dominant model: OR = 2.25, 95% CI = 1.42-3.57;the recessive model: OR = 3.05, 95% CI = 1.54-6.05). Moreover, there was no obvious publication bias.ConclusionOur findings suggested that G allele of IL-4R Q576R polymorphism is associated with increased risk of pediatric asthma. Anyhow, delicately-designed, large-scale studies should be conducted to further confirm the current outcomes.© 2022 Chen X et al.

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