• Oloruntoba A Ekun, Oloruntoba F Fagbemi, Esther N Adejumo, Oyeronke O Ekun, Kehinde S Wojuade, Folu M Oshundun, Florence O Adefolaju, and Sade R Oyegbami.
• Department of Medical Laboratory Science, College of Medicine University of Lagos.
• Afr Health Sci. 2022 Sep 1; 22 (3): 296306296-306.

BackgroundDiabetes mellitus is a chronic and progressive endocrine disorder that may result in macro and microvascular complications.ObjectiveThis study assessed some biochemical analytes in Nigerians who were recently (≤ 6 months) diagnosed with Type 2 diabetes mellitus (T2DM).Methods160 T2DM and 90 non-diabetic control participated in this study. Blood samples were collected and analyzed for Heart-type fatty acid-binding protein (HFABP), high sensitivity C-reactive protein (hs-CRP), electrolytes, lipid and renal profile parameters, glycated haemoglobin (HBA1C) and fasting blood glucose (FBG), using standard guidelines.ResultThe body mass index (BMI) of the T2DM volunteers was higher than control (P <0.001). The lipid profile, potassium, glucose, HBA1C, urea and creatinine values were elevated (P <0.001) while estimated glomerular filtration rate (eGFR) was lower (P<0.05) in diabetes. The median HFABP and hs-CRP were raised (P <0.05) in T2DM. Positive associations existed between FBG and urea (P <0.001), Creatinine and HBAIC (P <0.001). A logistic regression analysis, shows that an increased BMI, HBA1C, FBG, Cholesterol, urea and creatinine were associated with higher odds (p<0.001) of cardiovascular and renal complications.ConclusionElevated hs-CRP, glycated haemoglobin, urea and creatinine among T2DM increase the odds of cardiovascular and renal insults in this population.© 2022 Ekun OA et al.

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