• African health sciences · Sep 2022

    Development of a model for predicting mortality of breast cancer admitted to Intensive Care Unit.

    • Renfeng Huang, Wanming Wu, Yan Guo, Linyang Ou, Xumeng Gong, Chuansheng Yang, and Ruiwen Lei.
    • Department of head, neck and breast surgery, Yue Bei People's Hospital, Shaoguan, China.
    • Afr Health Sci. 2022 Sep 1; 22 (3): 155165155-165.

    BackgroundThere is still not a mortality prediction model built for breast cancer admitted to intensive care unit (ICU).ObjectivesWe aimed to build a prognostic model with comprehensive data achieved from eICU database.MethodsOutcome was defined as all-cause in-hospital mortality. Least absolute shrinkage and selection operator (LASSO) was conducted to select important variables which were then taken into logistic regression to build the model. Bootstrap method was then conducted for internal validation.Results448 patients were included in this study and 79 (17.6%) died in hospital. Only 5 items were included in the model and the area under the curve (AUC) was 0.844 (95% confidence interval [CI]: 0.804-0.884). Calibration curve and Brier score (0.111, 95% CI: 0.090-0.127) showed good calibration of the model. After internal validation, corrected AUC and Brier score were 0.834 and 0.116. Decision curve analysis (DCA) also showed effective clinical use of the model. The model can be easily assessed on website of https://breastcancer123.shinyapps.io/BreastCancerICU/.ConclusionsThe model derived in this study can provide an accurate prognosis for breast cancer admitted to ICU easily, which can help better clinical management.© 2022 Huang R et al.

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