• L de Jonge, Emilia Riggi, Luuk A van Duuren, Esther Toes-Zoutendijk, Cinzia Campari, Romano Sassatelli, Arrigo Arrigoni, Lorenzo Orione, Iris Lansdorp-Vogelaar, and Carlo Senore.
• Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, the Netherlands. Electronic address: l.dejonge.3@erasmusmc.nl.
• Prev Med. 2023 May 1; 170: 107488107488.

BackgroundPatterns of longitudinal adherence may predict advanced neoplasia (AN) detection in subsequent rounds of colorectal cancer (CRC) screening. However, after more than five rounds, it is important to obtain a simplified measure. The aim was to determine the best simplified measure of longitudinal adherence to predict AN detection in CRC screening.MethodsIndividuals with four invitations from a Dutch Fecal immunochemical testing (FIT-)based pilot study and two Italian FIT-based CRC screening programs were included. We calculated AN detection in the fourth round, stratified by prior adherence. Five simplified measures were compared to full information (permutations) using chi-squared goodness-of-fit: adherence previous invitation, consistency, frequency, frequency + adherence previous invitation, and proportion of invitations covered.ResultsAN detection in the fourth round was highly dependent on prior adherence behavior. For inconsistent adherence, detection in the fourth round was strongly dependent on frequency and time since last participation. The performance of the simplified measures to capture this variation differed considerably. 'Adherence previous invitation' scored worst in predicting AN detection. 'Frequency+adherence previous invitation' had lowest chi-squared goodness-of-fit.DiscussionThe simplified measure 'frequency+adherence previous invitation' is the best measure to reflect patterns of longitudinal adherence and could be used to emphasize to individuals the importance of CRC screening.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

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