• Fethiye Akgül, Can Tüzer, Yusuf Arslan, and Bünyamin Sevim.
• From the Department of Infectious Diseases and Clinical Microbiology (Akgül, Arslan); from the Department of Allergy and Immunology (Tüzer), Batman Training and Research Hospital, and from the TR Ministry of Health (Sevim), Batman Provincial Health Directorate, Batman, Turkey.
• Saudi Med J. 2023 Mar 1; 44 (3): 268276268-276.

ObjectivesTo evaluate the maternal and fetal clinical outcomes in SARS-CoV-2 infected pregnant women during the whole period of the pandemic in a single province in the southeast of Turkey.MethodsThis retrospective study included patients who were screened from the medical registration system and found to be infected with SARS-CoV-2 virus during pregnancy. The demographic, clinical, laboratory, and radiological features of all the patients were obtained and compared between groups classified as severe-critical and mild-moderate disease severity.ResultsThe mean age of all the cases was 29.0±5.3 years in the mild-moderate cases, and 30.1±5.5 years in the severe-critical cases. The rates of 3rd trimester, cesarean and premature birth, high body mass index (BMI), symptoms of cough and dyspnea, the presence of comorbidities, and hypothyroidism were significantly higher in the severe-critical cases than in the mild-moderate group. In the univariate analyses, BMI, dyspnea, cough, maternal complication rate, the neutrophil/lymphocyte ratio, the values of white blood cells, procalcitonin, high-sensitive C-reactive protein, D-dimer, ferritin, aspartate aminotransferase, and alanine aminotransferase were detected as significant risk factors. In the multivariate analysis, only procalcitonin was a significant factor.ConclusionIn the 3rd trimester of pregnancy, obesity and hypothyroidism were found to be risk factors for severe-critical cases of COVID-19 infection, and the clinical course was more severe with a higher rate of mortality in the recent period of the pandemic.Copyright: © Saudi Medical Journal.

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