[Clinical, biochemical and epidemiological features of

Rev Med Interne · May 2023

Case Reports

[Clinical, biochemical and epidemiological features of macro-AST preceding inflammatory bowel disease diagnosis by several years].

An isolated elevation of aspartate aminotransferase (AST) is a diagnostic issue. Macro-aspartate aminotransferase (macro-AST) corresponds to the formation of complexes between AST and immunoglobulins. ⋯ The objective of this work is to increase awareness of this benign disorder among clinicians and biologists, as well as to aid in prescribing only the required tests.

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- Z Nadour, B Rosenbaum, H Blons, M A Loriot, J-L Paul, and N Pallet.
- Service de biochimie, hôpital européen Georges-Pompidou, assistance publique-hôpitaux de Paris (AP-HP), 75013 Paris, France. Electronic address: zahia.nadour@aphp.fr.
- Rev Med Interne. 2023 May 1; 44 (5): 259262259-262.
IntroductionAn isolated elevation of aspartate aminotransferase (AST) is a diagnostic issue. Macro-aspartate aminotransferase (macro-AST) corresponds to the formation of complexes between AST and immunoglobulins.Case ReportWe report the case of a patient with macro-AST identified several years before the onset of inflammatory bowel disease (IBD). A 6-year retrospective analysis in our laboratory identified only one case out of 42 540 adult patients.ConclusionThe objective of this work is to increase awareness of this benign disorder among clinicians and biologists, as well as to aid in prescribing only the required tests.Copyright © 2023 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

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[Clinical, biochemical and epidemiological features of macro-AST preceding inflammatory bowel disease diagnosis by several years].

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