• Yukun Jia, Yu Xiong, Zhan Peng, and Guangye Wang.
• Department of Orthopaedics, The People's Hospital of Baoan, Shenzhen, China.
• J Coll Physicians Surg Pak. 2023 Mar 1; 33 (3): 266269266-269.

ObjectiveTo assess the risk of cardiovascular mortality (CVM) in patients with osteosarcoma.Study DesignDescriptive study. Place and Duration of the Study: Department of Orthopaedics, The People's Hospital of Baoan, Shenzhen, Guangdong, China, from 1st January 2019 to 1st January 2022.MethodologyData on patients diagnosed with osteosarcoma, between 1975 and 2019, were obtained from the surveillance, epidemiology, and end results (SEER) database. Using the Nelson-Aalen cumulative risk curve to assess the risk of CVM in patients with osteosarcoma. Competing risk models were used for identifying and analysing independent risk factors for CVM in the patients.ResultsData from a total of 1335 patients with osteosarcoma were obtained from the SEER database. The characteristics of patients with osteosarcoma independently related with a high risk of CVM were age over 65 years (HR: 2.528; 95% CI: 1.156 - 5.527), race of other categories (HR: 1.498; 95% CI: 1.044 - 2.151), and exposure radiotherapy (HR: 0.493; 95% CI: 0.244 - 0.998). Receiving chemotherapy was independently associated with a low risk of CVM (HR: 1.911; 95% CI: 1.016 - 3.593).ConclusionCardiovascular disease death from osteosarcoma was significantly associated with older age at diagnosis, race other class, receiving radiation therapy, and not undergoing chemotherapy.Key WordsOsteosarcoma, Cancer risk factors, Epidemiology.

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