• Eray Kemahli, Ugur Uyeturk, Ayhan Cetinkaya, Sevilay Erimsah, Ummugul Uyeturk, and Adnan Gucuk.
• Department of Urology, Bolu Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
• J Coll Physicians Surg Pak. 2023 Mar 1; 33 (3): 319324319-324.

UnlabelledABSTRACT       Objective: To assess the effectiveness of utilising N-acetyl cysteine (NAC) to treat tissue damage brought on by undescended testis (UT) in rats after orchiopexy.Study DesignExperimental study. Place and Duration of the Study: Bolu Abant İzzet Baysal University, Bolu, Turkey, from January 2018 to June 2020.MethodologyThe UT model was created by administering flutamide to pregnant rats. Four groups of animals were created as the control group (offsprings of pregnant rats without flutamide), group II (UT), group III (UT + orchiopexy), and group IV (UT + orchiopexy + NAC); each containing eight animals.ResultsGroup IV had a higher level of glutathione peroxidase than groups III and II (p=0.001 and p=0.002, respectively). Malondialdehyde was reduced in group IV compared with groups III and II (both p<0.001). There were differences in mean apoptotic cell counts (ACC) among the groups (p<0.001). ACC in group IV was lower than in group III (p<0.001). Sperm counts were higher in group IV than ın groups III and II, and in group III they were higher than group II (p<0.001 all) and similar between groups IV and control group (p=0.102).ConclusionOrchiopexy reduced UT-related testicular damage, additionally using NAC following orchiopexy may further reduce testicular damage through its antioxidant effects.Key WordsUndescended testis, Testis damage, Orchiopexy, N-acetyl cysteine, Antioxidant.

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