• Arch Med Sci · Jan 2023

    Eicosanoids in human heart failure: pilot study of plasma epoxyeicosatrienoic and dihydroxyeicosatrienoic acid levels.

    • Petr Kala, Tomas Hnat, Karolina Padrova, Karel Kotaška, and Josef Veselka.
    • Department of Cardiology, University Hospital Motol and 2 Faculty of Medicine, Charles University, Prague, Czech Republic.
    • Arch Med Sci. 2023 Jan 1; 19 (2): 513517513-517.

    IntroductionThe role of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, remains unclear in human heart failure (HF).MethodsWe enrolled 50 patients with HF to measure plasma 14,15-EET and 14,15-DHET levels using commercial ELISA kits and compared them with 25 age- and sex-matched controls.ResultsBoth of the measured eicosanoids were significantly higher in the HF group: 14,15-EET (91.3 ±25.7 ng/ml vs. 64.95 ±35.4 ng/ml) and 14,15-DHET (10.58 ±2.06 ng/ml vs. 9.07 ±1.60 ng/ml), p for both < 0.001.ConclusionsWe found that peripheral plasma eicosanoid (14,15-EET, 14,15-DHET) levels are raised in patients with HF compared to age- and sex-matched controls.Copyright: © 2023 Termedia & Banach.

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