• Nahla A Alshaikh, Siddig I Abdelwahab, Mahmoud M Habibullah, Ahmed A Jerah, Mohammed A Bakri, and Yahia A Kaabi.
• From Medical Laboratory Technology Department (Alshaikh, Habibullah, Jerah, Kaabi), Faculty of Applied Medical Sciences, Jazan University; from the Medical Research Center (Abdelwahab), Jazan University; and from the Department of Medical Laboratories (Bakri), King Fahd Central Hospital, Jizan, Kingdom of Saudi Arabia.
• Saudi Med J. 2023 Apr 1; 44 (4): 363367363-367.

ObjectivesTo investigate the prevalence of rs2015 (T>G) and rs2241703 (G>A) polymorphisms in the miRNA-SIRT2 gene in Saudi Arabia and their possible associations with type 2 diabetes mellitus (T2DM).MethodsBlood samples were collected from 428 participants from Jazan University Hospital, Jazan, Saudi Arabia between September 2021 and June 2022 and subjected to TaqMan single-nucleotide polymorphisms (SNP) genotyping assay for rs241703 (G>A) and rs2015 (G>T). Genotype frequencies were determined in control (n=217).ResultsThe A allele of rs2241703 was undetected in our population, and all samples carried the GG genotype. The rs2015 SNP frequency was 29.4% for GG, 45.6% for GT, and 24% for TT. However, logistic regression analysis of the dominant inheritance model showed no association between the T allele and T2DM calculated odds ratio [OR]=0.80, 95% confidence interval=0.53 to 1.20, p=0.301).ConclusionAlthough rs2241703 SNP of Sirtuins 2 is not present, rs2015 SNP is highly prevalent in Saudi Arabia, but no direct link was identified with T2DM.Copyright: © Saudi Medical Journal.

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