• Abdullah S Basuliman, Mohammed A Malabarey, Fahad W Abousamak, Bader Y Alyousef, Saleh S Alrabea, Rakan A Alshabibi, and AseriZohair A AlZAAFrom the College of Medicine (Basuliman, Alyousef, Alrabea), King Saud bin Abdulaziz University for Health Sciences; from the Departments of Emergency Medicine and Critical Care (Malabarey, Al Aseri), College of Medicine, King Saud Univ.
• From the College of Medicine (Basuliman, Alyousef, Alrabea), King Saud bin Abdulaziz University for Health Sciences; from the Departments of Emergency Medicine and Critical Care (Malabarey, Al Aseri), College of Medicine, King Saud University; from the Department of Clinical Sciences (Al Aseri), and from the College of Medicine (Abousamak, Alshabibi), Dar Al Uloom University; and from the Saudi Red Crescent Authority (Abousamak), Riyadh, Kingdom of Saudi Arabia.
• Saudi Med J. 2023 Apr 1; 44 (4): 379384379-384.

ObjectivesTo identify patients who are at risk for a first cardiovascular event, mitigate the risk, and institute early intervention. The triglyceride to high-density lipoprotein-C (TG/HDL-C) ratio has been found to be a very useful biomarker for directing treatment and prevention therapy.MethodsThis retrospective cross-sectional study included adult patients (aged >18 years) experiencing first-time acute coronary syndrome (ACS). We examined all patient databases for a definite diagnosis of angina, non-ST segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI). Lipid profiles were obtained prior to or at the time of admission.ResultsA total of 265 patients were included in the study (mean age 57.83 ± 11.4 years) and 79.2% were men. Male gender, presence of diabetes, raised total cholesterol, raised low-density lipoprotein (LDL), and raised troponin level on admission were significantly positively correlated with STEMI (p=0.004, p=0.001, p<0.001, and p<0.001), whereas TG/HDL-C ratio was significantly negatively correlated with STEMI (p=0.048), while there was no significant results with NSTEMI (p=0.264) and angina (p=0.326). Total cholesterol and raised low-density lipoprotein (LDL) were significantly positively correlated with NSTEMI (p=0.013 and p=0.024).ConclusionPatients with first-time ACS may not have an increased TG/HDL-C ratio. High LDL levels had the most significant association with an ACS event, along with total cholesterol and diabetes. Further research is needed on a larger scale to determine the association of TG/HDL-C ratio with ACS and differentiate the different types of ACS events according to their clinical and laboratory characteristics.Copyright: © Saudi Medical Journal.

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