• Stephanie S Faubion, Felicity Enders, Mary S Hedges, Rajeev Chaudhry, Juliana M Kling, Chrisandra L Shufelt, Mariam Saadedine, Kristin Mara, Joan M Griffin, and Ekta Kapoor.
• Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL; Mayo Clinic Women's Health, Mayo Clinic, Rochester, MN. Electronic address: faubion.stephanie@mayo.edu.
• Mayo Clin. Proc. 2023 Jun 1; 98 (6): 833845833-845.

ObjectiveTo evaluate the impact of menopause symptoms on work outcomes and to assess the estimated economic impact.Patients And MethodsWomen aged 45 to 60 years receiving primary care at 1 of the 4 Mayo Clinic sites were invited to participate in a survey study (Hormones and ExpeRiences of Aging) from March 1 through June 30, 2021. A total of 32,469 surveys were sent, with 5219 responses (16.1% response rate). Of the 5219 respondents, 4440 (85.1%) reported current employment information and were included in the study. The primary outcome was self-reported adverse work outcomes related to menopause symptoms assessed by the Menopause Rating Scale (MRS).ResultsThe mean age of the 4440 participants was 53.9±4.5 years, with the majority being White (4127 [93.0%]), married (3398 [76.5%]), and educated (2632 [59.3%] college graduate or higher); the mean total MRS score was 12.1, signifying moderate menopause symptom burden. Overall, 597 women (13.4%) reported at least one adverse work outcome due to menopause symptoms; 480 women (10.8%) reported missing work in the preceding 12 months (median, 3 days missed). The odds of reporting an adverse work outcome increased with increasing menopause symptom severity; women in the highest quartile of total MRS scores were 15.6 (95% CI, 10.7 to 22.7; P<.001) times more likely to have an adverse work outcome vs those in the first quartile. Based on workdays missed due to menopause symptoms, we estimate an annual loss of $1.8 billion in the United States.ConclusionThis large cross-sectional study identified a major negative impact of menopause symptoms on work outcomes and the need to improve medical treatment for these women and make the workplace environment more supportive. Additional studies are needed to confirm these findings in larger and more diverse groups of women.Copyright © 2023 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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