• Xin He, Jia You, Ying Chen, Hao Tang, Jingni Ran, and Deyu Guo.
• Department of Pathology, Guiqian International General Hospital, Guiyang, China.
• Medicine (Baltimore). 2023 May 5; 102 (18): e33707e33707.

RationaleMucoepidermoid carcinoma (MEC) is one of the most common malignant tumors in salivary glands, with specific histomorphological and molecular characteristics. MEC occurring in breast is more rare.Patient ConcernsWe reported 3 cases of female breast mass, diagnosed as benign nodules by ultrasound.DiagnosesThe first 2 cases were pathological diagnosed as breast MEC, low grade, and the third case as breast MEC, medium grade.InterventionsAfter pathological diagnosis, 3 patients have expanded the scope of breast resection and lymph node dissection, with negative margin and no lymph node metastasis.OutcomesIn the follow-up observation, the first case was followed up for 24 months, the second case was followed up for 30 months, and the third case was followed up for 12 months. All patients had a good prognosis without evidence of recurrence and metastasis.ConclusionBreast MEC is extremely rare and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 negative breast cancer with a good prognosis, which is different from other highly malignant triple-negative breast cancers. reviewed its clinicopathologic morphological characteristics, immunohistochemical markers and molecular characteristics, prognosis and clinical treatment through literature, in order to understanding its clinicopathology and providing reference for clinical precise treatment.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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