• Jun Ge, Hao Li, Jia-Qi Yang, Yuan Yue, Sheng-Yu Lu, Hong-Yun Nie, Tao Zhang, Pei-Ming Sun, Hong-Feng Yan, Hong-Wei Sun, Jian-Wu Yang, Jin-Lian Zhou, and Yan Cui.
• Department of General Surgery, Strategic Support Force Medical Center, Beijing 100101, China.
• Medicine (Baltimore). 2023 May 12; 102 (19): e33698e33698.

AbstractHepatic macrophages are a complex population of cells that play an important role in the normal functioning of the liver and in liver diseases. Autophagy, as a maintainer of cellular homeostasis, is closely connected to many liver diseases. And its roles are not always beneficial, but manifesting as a double-edged sword. The polarization of macrophages and the activation of inflammasomes are mediated by intracellular and extracellular signals, respectively, and are important ways for macrophages to take part in a variety of liver diseases. More attention should be paid to autophagy of hepatic macrophages in liver diseases. In this review, we focus on the regulatory role of hepatic macrophages' autophagy in a variety of liver diseases; especially on the upstream regulator of polarization and inflammasomes activation of the hepatic macrophages. We believe that the autophagy of hepatic macrophages can become a potential therapeutic target for management of liver diseases.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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