• Dania A Monagel, Aletani Tala, Alghamdi Arwa, Banjar Sereen, Hakeem Ilana, Hannef Deena, Ahmed Omaima, and Elimam Naglla.
• From the College of Medicine (Monagel, Tala, Arwa, Sereen, Ilana), King Saud bin Abdulaziz University for Health Sciences; from the Department of Medical Researches (Monagel), King Abdullah International Medical Research Center; from the Department of Oncology (Monagel, Omaima, Naglla), Ministry of the National Guard- Health Affairs; from the Center of Excellence in Genomic Medicine Research (Deena), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
• Saudi Med J. 2023 May 1; 44 (5): 498499498-499.

ObjectivesTo investigate the clinical and pathological characteristics of extracranial germ cell tumors (GCTs) in children aged 0-168 months treated at the National Guard Hospital, Jeddah, Saudi Arabia from 1990 to 2020.MethodsIn this retrospective analysis, the data for all cases of GCTs were collected from 1990 to 2020. Statistical analyses were carried out using JMP software. The data was divided into 4 main categories: demographics, pathological/clinical features, recurrence, treatment and outcome.ResultsThe study included 50 patients, with a mean age at diagnosis of 56.52 months. The median follow-up duration was 30 months. Most tumors were in the gonads, and among the extragonadal tumors, the sacro-coccyx was the most frequent site of the disease.The most common histological subtype of GCTs is yolk sac tumor, accounting for 28% of cases. Of the 50 patients, 46% received chemotherapy, and 54% underwent surgery without chemotherapy. Ten (20%) patients experienced recurrence after treatment. At the last follow-up, 96% of the patients were alive, and only 2 of the patients died due to advanced disease.ConclusionOur findings were comparable to international data, but improvement in surveillance is required for long-term survivors.Copyright: © Saudi Medical Journal.

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