• Jumanah J Alfuwayris, Amal M Almulhim, Mohammed A Almansour, Marzouq A Albadi, Ibrahim A Alhomood, Faisal Alblewi, and Abdullah U Althemery.
• From the Department of Rheumatology (Alfuwayris), Ministry of the National Guard - Health Affairs, King Abdullah International Medical Research Center, from the Department of Rheumatology (Alfuwayris), King Saud bin Abdulaziz University for Health Sciences; from Department of Rheumatology, King Fahad Medical City (Almulhim, Almansour, Alhomood, Alblewi); from Rheumatology Division (Albadi), Security Forces Hospital, Riyadh; and from Department of Clinical Pharmacy (Althemery), College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia.
• Saudi Med J. 2023 May 1; 44 (5): 486491486-491.

ObjectivesTo understand the most common type and clinical manifestations of associated vasculitis (AAV) in the Saudi Arabia.MethodsThis retrospective study was conducted at King Fahad Medical City and the Security Forces Hospital Program, Riyadh, Saudi Arabia, between January 2014 and May 2022. Patients aged ≥18 years were included in the study and diagnosed based on clinical manifestations, serology, or histopathology according to the EMA algorithm. Univariate analysis was carried out to compare different groups; a series of independent samples t-tests was applied for continuous data.ResultsA total of 53 patients were enrolled: eosinophilic granulomatosis with polyangiitis (EGPA), granulomatosis with polyangiitis (GPA), and microscopic polyangiitis (MPA). Overall, proteinase-3 was the most prevalent (52.8%), and myeloperoxidase, myeloperoxidase MPO was the least prevalent antineutrophil cytoplasmic antibody (ANCA)-type (18.9%) among patients; other patients showed negative ANCA test results. The clinical manifestations differed significantly between EGPA and GPA groups in pulmonary, neurological, cardiological, and renal signs and symptoms (p<0.05); there was a higher incidence of the former 3 in the EGPA group. Although upper airway was predominant in all groups, there was no statistical difference between both groups.ConclusionThis study validated international reports on AAV clinical manifestations in the Saudi population. The GPA was associated with more upper airway and pulmonary signs and symptoms. Further investigation is needed to understand the treatments and quality of life of patients with AAV.Copyright: © Saudi Medical Journal.

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