• Zheng Rong, Le Yang, Yue Chen, Yan Qin, Cai-Yan Cheng, Jun Zhao, Long-Fei Li, Xue Ma, Yu-Mei Wu, Shui-Bing Liu, Yan-Ni Liang, and Ming-Gao Zhao.
• School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
• Mol Pain. 2023 Jan 1; 19: 1744806923117763417448069231177634.

AbstractChronic pain, along with comorbid psychiatric disorders, is a common problem worldwide. A growing number of studies have focused on non-opioid-based medicines, and billions of funds have been put into digging new analgesic mechanisms. Peripheral inflammation is one of the critical causes of chronic pain, and drugs with anti-inflammatory effects usually alleviate pain hypersensitivity. Sophoridine (SRI), one of the most abundant alkaloids in Chinese herbs, has been proved to exert antitumor, antivirus and anti-inflammation effects. Here, we evaluated the analgesic effect of SRI in an inflammatory pain mouse model induced by complete Freund's adjuvant (CFA) injection. SRI treatment significantly decreased pro-inflammatory factors release after LPS stimuli in microglia. Three days of SRI treatment relieved CFA-induced mechanical hypersensitivity and anxiety-like behavior, and recovered abnormal neuroplasticity in the anterior cingulate cortex of mice. Therefore, SRI may be a candidate compound for the treatment of chronic inflammatory pain and may serve as a structural basis for the development of new drugs.

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