• Hacer Gizem Gercek, Berna Gunduz Citir, and Aysegul Bukulme.
• Bratisl Med J. 2023 Jan 1; 124 (7): 503507503-507.

ObjectiveThe studies on the pathogenesis of schizophrenia reported data indicating that abnormal immune responses might play a role in the development of schizophrenia. One of the markers of systemic inflammation is the neutrophil-to-lymphocyte ratio (NLR). In our study, the relationship between the early-onset schizophrenia, NLR, platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) was investigated.Materials And MethodsThe study included 30 patients and 57 healthy controls matched in age and gender. Hematological parameters and Clinical Global Impressions Scale (CGI) scores were obtained from the medical records of the patients. Hematological parameters in the patient group were compared to those in the healthy control groups. The relationship between inflammation markers and CGI scores was investigated in the patient group.ResultsNLR, and neutrophil and platelet counts were found to be higher in the patient group as compared to the control group. A positive correlation was found between NLR and CGI scores.ConclusionThe results of the study support the multisystem inflammatory process model related to schizophrenia, which was revealed in previous studies, also in children and adolescents in the patient group (Tab. 4, Ref. 36). Text in PDF www.elis.sk Keywords: neutrophil-to-lymphocyte ratio, inflammation, early‑onset schizophrenia.

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