• Serafima Tazina, Tatiana Fedorova, Natalya Semenenko, Yuliya Ilina, Alexander Mamonov, and Chavdar Pavlov.
• Bratisl Med J. 2023 Jan 1; 124 (8): 622629622-629.

BackgroundInfective endocarditis (IE) is most often caused by bacteria.ObjectivesThe aim of this work is the research of the dynamics of the clinical laboratory and instrumental methods of the diagnostics during the period of two decades.MethodsThe data of 241 patients with infective endocarditis (IE) who were treated at the State Clinical Hospital named after Botkin S.P. was included in the research. 121 patients were observed from 2011 till 2020 (the first group) and 120 patients - from 1997 to 2004 (the second test group). These data included age and social structure of pathology, peculiarities of clinical picture, laboratory, and instrumental methods of research, as well as the outcome of the disease. We studied the concentrations of procalcitonin and presepsin in patients hospitalized after 2011. We observed pathomorphism of the modern IE.ResultsTo discover the bacteriological origin of the disease, we found the diagnostic evaluation of inflammation, procalcitonin, and presepsin activities, using C-reactive protein, important. We observed decrease in the number of general and hospital deaths.ConclusionsThe knowledge of the IE peculiarities during the IE progression is essential for timely diagnosis and more accurate pathology prediction (Fig. 5, Ref. 38). Text in PDF www.elis.sk Keywords: infectious endocarditis, valve apparatus disease, thromboembolic complications, immunocomplex complications, procalcitonin, presepsin.

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