• Channi Wu, Lin Wang, Lan Zhang, Yangdan Ni, Zhiyong Wang, and Yichen Qu.
• Department of Gastroenterology, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, China.
• Medicine (Baltimore). 2023 May 26; 102 (21): e33868e33868.

RationalCollagenous gastritis (CG) is rarely encountered in clinical practice. Here, we reported a case of CG with iron-deficiency anemia as the main symptom.Patient ConcernsThe patient was a 26-year-old woman who sought medical advice with a chief complaint of recurrent upper abdominal distention and anemia since the last 3 years.DiagnosesGastroscopy at admission showed diffuse nodular mucosa. The pathology showed the formation of a belt hyperplasia of collagen in the superficial mucosa along with the infiltration of inflammatory cells. The subepithelial collagen band was 17.68 to 35.73-μm thick and tested positive for Masson staining, thereby confirming the diagnosis of CG.InterventionsA polysaccharide iron complex capsule was given in a dosage of 0.3 t.i.d., p.o. in combination with an omeprazole capsule (20 mg q.d. p.o).OutcomesThe symptoms (upper abdominal distention and anemia) were ameliorated after 8-week treatment. Blood routine showed that the hemoglobin level rose to 91 g/L.LessonsIt is difficult to diagnose CG. Hence, a comprehensive examination based on clinical manifestations, endoscopic findings, and pathological features is required.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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