• Guofang Ma, Yuefang Pan, Chaoyi Qu, and Feng Li.
• Department of Emergency Medicine, The First People's Hospital of Linping District, Hangzhou, Zhejiang, China.
• Medicine (Baltimore). 2023 May 26; 102 (21): e33807e33807.

BackgroundThe efficacy of vericiguat was elusive for heart failure. This meta-analysis aimed to explore the efficacy of vericiguat for heart failure.MethodsPubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases have been searched through October 2022 and we included randomized controlled trials reporting the effect of vericiguat versus placebo in patients with heart failure.ResultsFour randomized controlled trials were included in the meta-analysis. Compared with placebo group for heart failure, vericiguat treatment was able to substantially improve the composite outcome of cardiovascular death or heart failure hospitalization (odds ratio [OR] = 0.87; 95% confidence interval [CI] = 0.78 to 0.97; P = .02), but unraveled no obvious impact on hospitalization for heart failure (OR = 0.89; 95% CI = 0.79 to 1.00; P = .05), death from cardiovascular causes (OR = 0.93; 95% CI = 0.77 to 1.13; P = .48), death from any cause (OR = 0.96; 95% CI = 0.84 to 1.10; P = .56), adverse events (OR = 0.95; 95% CI = 0.84 to 1.08; P = .42) or serious adverse events (OR = 0.92; 95% CI = 0.82 to 1.02; P = .12).ConclusionsVericiguat treatment may benefit to treat heart failure.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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