• Chien-Hung Lu, Wei-Yu Kao, Chun-Chao Chang, and Yu-An Kan.
• Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
• Medicine (Baltimore). 2023 May 26; 102 (21): e33869e33869.

RationaleColonic extranodal mucosa-associated lymphoid tissue lymphoma as a cause of hematochezia is rare. Here, we report a case of colonic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALToma) with presentation of freshy bloody stool and successfully treated by endoscopic mucosal resection.Patient ConcernsThis case was a 69-year-old woman with history of hypertension, reflux esophagitis, and peptic ulcer. She had several episodes of hematochezia and thus sought medical attention at the outpatient clinic.DiagnosesColonoscopy revealed a 12-mm semipedunculated lesion in the ascending colon. Histopathological examination and immunochemistry were compatible with colonic extranodal mucosa-associated lymphoid tissue lymphoma.InterventionsEndoscopic mucosal resection was done for tumor removal and hemoclipping was done to achieve hemostasis.OutcomesThe patient remained well without recurrence during 3 years of outpatient follow-up.LessonColonic MALToma is a rare disease, and could present as hematochezia. En bloc endoscopic resection could achieve long-term remission. The prognosis of colonic MALToma is excellent with its indolent characteristics.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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